What Is Microdosing Psilocybin? Microdosing psilocybin means taking a very small, sub-perceptual dose of psilocybin mushrooms — typically 50 to 300 milligrams. At these doses, you won’t experience a psychedelic “trip.” Instead, many users report subtle improvements in focus, creativity, mood, and overall well-being over time. The practice has gained mainstream attention thanks to research...